Le scansioni FDDNP-PET eseguite prima e dopo il trattamento hanno suggerito che i benefici comportamentali e cognitivi sono associati a diminuzioni di accumuli di placche e ammassi nelle regioni del cervello che modulano l'umore e la memoria.
I benefici cognitivi della curcumina potrebbero derivare dai suoi effetti anti-infiammatori e / o anti-amiloidi nel cervello
Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
Gary W. Small, M.D., Prabha Siddarth, Ph.D., Zhaoping Li, M.D., Ph.D., Karen J. Miller, Ph.D., Linda Ercoli, Ph.D., Natacha D. Emerson, M.A., Jacqueline Martinez, M.B.A., M.S., Koon-Pong Wong, Ph.D., Jie Liu, Ph.D., David A. Merrill, M.D., Ph.D., Stephen T. Chen, M.D., Susanne M. Henning, Ph.D., R.D., Nagichettiar Satyamurthy, Ph.D., Sung-Cheng Huang, D.Sc., David Heber, M.D., Ph.D., Jorge R. Barrio, Ph.D.
This is the first long-term (18 months) double-blind, placebo controlled trial of a bioavailable form of curcumin (Theracurmin® containing 90 mg of curcumin twice daily) in non-demented adults.
We found that daily oral Theracurmin led to significant memory and attention benefits.
FDDNP-PET scans performed pre- and post-treatment suggested that behavioral and cognitive benefits are associated with decreases in plaque and tangle accumulation in brain regions modulating mood and memory.
Curcumin’s cognitive benefits may stem from its anti-inflammatory and/or anti-amyloid brain effects.